Elucidating Mechanisms of Resistance to Therapeutic Inhibition of Rna Polymerase I Transcription

First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: Results of a phase I dose-escalation study

A Khot, N Brajanovski, DP Cameron, N Hein, KH Maclachlan, E Sanij, J Lim, J Soong, E Link, P Blombery, ER Thompson, A Fellowes, KE Sheppard, GA McArthur, RB Pearson, RD Hannan, G Poortinga, SJ Harrison

2019-08-01

RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and it..